Variant BDNF Val66Met Polymorphism Affects Extinction of Conditioned Aversive Memory
نویسندگان
چکیده
منابع مشابه
Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory.
Brain-derived neurotrophic factor (BDNF) plays important roles in activity-dependent plasticity processes, such as long-term potentiation, learning, and memory. The recently reported human BDNF Val66Met (BDNF(Met)) polymorphism has been shown to lead to altered hippocampal volume and impaired hippocampal-dependent memory and is associated with a variety of neuropsychiatric disorders. There are ...
متن کاملVariant BDNF Val 66 Met polymorphism affects extinction of conditioned aversive memory Abbreviated title : BDNF Val 66 Met and extinction of aversive memory
Department of Neurobiology, School of Medicine, Shandong University, Jinan, Shandong 250012, China; Graduate Program in Neuroscience, Weill Cornell Medical College, New York, NY 10065; Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, New York 10065; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chines...
متن کاملBDNF val66met polymorphism affects aging of multiple types of memory.
The BDNF val66met polymorphism (rs6265) influences activity-dependent secretion of brain-derived neurotrophic factor in the synapse, which is crucial for learning and memory. Individuals homozygous or heterozygous for the met allele have lower BDNF secretion than val homozygotes and may be at risk for reduced declarative memory performance, but it remains unclear which types of declarative memo...
متن کاملThe BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine (val) to methionine (met) substitution in the 5' pro-region of the human BDNF protein. In human subjects, the met allele was associated with poorer episodic memory, abnormal hippocampal activation assayed with fMRI, and low...
متن کاملThe functional BDNF Val66Met polymorphism affects functions of pre-attentive visual sensory memory processes.
The brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is involved in nerve growth and survival. Especially, a single nucleotide polymorphism (SNP) in the BDNF gene, Val66Met, has gained a lot of attention, because of its effect on activity-dependent BDNF secretion and its link to impaired memory processes. We hypothesize that the BDNF Val66Met polymorphism may have ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2009
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5539-08.2009